Featured Publications

As a learning organization committed to enhancing the health of current and future generations through research, the CVC relentlessly pursues the generation, translation, and dissemination of new knowledge addressing unmet clinical needs. This section highlights important publications produced by the CVC faculty and our body of research in recent months.

View CVC’s full publication archive here.


Population-level incidence and outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA): Insights from the Alberta contemporary acute coronary syndrome patients invasive treatment strategies (COAPT) study.

Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, Brass N, Armstrong PW, Kaul P.
Int J Cardiol. 2018;264:12-17.

MINOCA is a known clinical conundrum with limited investigation. This study followed roughly 36,000 Alberta heart patients over a period of 12 years, and is considered to be the world’s first long term examination of this little-understood condition. Historically, MINOCA has been seen as a benign condition, and patients are commonly sent home without any treatment or lifestyle advice. The authors of this study concluded that the population-level incidence of MINOCA is approximately 5%, and despite their apparently benign anatomic findings, efforts must be made to improve secondary prevention strategies to reduce the burden of long-term adverse outcomes in this population.

In addition to the publication in the International Journal of Cardiology, Dr. Bainey also spoke about his research on MINOCA in a recent article from the Edmonton Journal.

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The effect of provider affiliation with a primary care network on emergency department visits and hospital admissions.

McAlister FA, Bakal JA, Green L, Bahler B, Lewanczuk R
CMAJ. 2018;190:E276-E284.

In this article the authors compared health outcomes associated with primary care networks versus conventional primary care. Their analysis suggests that a province-wide program to promote team-based primary care is a feasible and effective way to reduce use of emergency departments for Patient Medical Home indicator conditions or for any cause (a potential marker of improved access to care). Although physician pay for performance is often emphasized in efforts to reform primary care, the potential impact on the population seen with the Alberta Primary Care Network natural experiment is larger than has been seen with incentive payments for primary care physicians in various settings.

This article, along with lead author Dr. Finlay McAlister were also featured in Medical Xpress and EurekAlert.

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Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy.

Mehta SR, Bainey KR, Cantor WJ, Lordkipanidzé M, Marquis-Gravel G, Robinson SD, Sibbald M, So DY, Wong GC, Abunassar JG, Ackman ML, Bell AD, Cartier R, Douketis JD, Lawler PR, McMurtry MS, Udell JA, van Diepen S, Verma S, Mancini GBJ, Cairns JA, Tanguay JF; members of the Secondary Panel.
Can J Cardiol. 2018;34:214-233.

Antiplatelet therapy (APT) has become an important tool in the treatment and prevention of atherosclerotic events, particularly those associated with coronary artery disease. The present update to the 2011 and 2013 Canadian Cardiovascular Society APT guidelines incorporates new evidence on how to optimize APT use, particularly in situations in which few to no data were previously available. In addition to specific recommendations, the authors provide values and preferences and practical tips to aid the practicing clinician in the day to day use of these important agents.

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Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: a meta-analysis of randomised clinical trials.

Sepehrvand N, James SK, Stub D, Khoshnood A, Ezekowitz JA, Hofmann R.
Heart. 2018. pii: heartjnl-2018-313089.

The authors of this article sought to synthesise the evidence from randomised clinical trials to investigate the effects of supplemental oxygen therapy in patients with suspected or confirmed acute myocardial infarction (AMI). This meta-analysis showed that oxygen therapy did not reduce the risk of in-hospital or 30-day mortality in those with suspected or confirmed AMI. It also had no effect on the cardiac troponin levels or the infarct size as defined by cardiac MRI.

Dr. Justin Ezekowitz spoke further about his and Dr. Nariman Sepehrvand’s meta-analysis research with TCTMD.

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