Services
- Thought Leadership
  
  With their depth of knowledge and experience, CVC thought leaders are able to both understand and address the multiple challenges associated with the regulatory, financial and operational aspects of clinical research. Some key elements of their research-related …
  
  Clinical Trials Management
  
  With over 20 years of experience in Clinical Trial Operations for Phase II/III/IV and investigator initiated studies, our team brings the expertise and knowledge to deliver a high quality and well executed trial from study …
  
  Biostatistics
  
  The biostatisticians at the CVC provide statistical expertise to study design and analysis, and have experience with a wide variety of data sources. They participate in innovative primary and secondary research in cardiovascular medicine in …
  
  Health Economics and Quality of Life
  
  The CVC has a long history using natural “experiments” in the form of inter-country comparisons to draw inferences about the return on investment in medical care. In the modern era of cost conscious medicine, clinical …
  
  Population Health Surveillance
  
  The CVC is actively involved in examining population-level issues related to access, delivery, treatment, and outcomes of heart disease in Alberta and Canada. Healthcare administrative databases have become a cornerstone in the process of assessing …
  
  Core Labs
  
  ECG Core Lab The ECG Core Laboratory specializes in the processing and analysis of electrocardiographic data from large-scale clinical trials and investigator-initiated research projects. This laboratory has had a major role as the primary coordinating laboratory …
  
  Business Operations
  
  The business office is fundamental to the organizational and financial underpinnings of the CVC. This group is responsible for overseeing all aspects of finance, human resources, IT infrastructure, marketing, and legal matters involving the CVC’s …
Clinical Research
- Clinical Trials
  
  Below you will find a list of trials we are currently working on, some which are currently recruiting and others which are in the follow up or closeout phase. If you are interested in learning …
  
  Population Based Research
  
  Below you will find information about the population based research projects that are currently underway at the CVC. Through the interrogation of registries and population health data, the CVC is steadfastly dedicated to our organization’s …
  
  COVID-19 Projects
  
  For a list of Canadian-led COVID-19-related projects (and contact information), please see the link below: Canadian COVID-19 Collaboration Trial Inventory (PDF)
Publications
- Featured Publications
  
  As a learning organization committed to enhancing the health of current and future generations through research, the CVC relentlessly pursues the generation, translation, and dissemination of new knowledge addressing unmet clinical needs. This section highlights …
  
  Publication Archives
  
  Canadian Cardiac Chronicle
  
  The Canadian Cardiac Chronicle is a quarterly newsletter that includes information about the CVC's current trials and upcoming projects, as well as a list of recent publications from our faculty. The Chronicle is distributed to …
  
  Annual Reports
  
  As an Academic Research Organization, the Canadian VIGOUR Centre is held to a high standard of both fiscal and academic responsibility. Browse through our current and past Annual Reports to find out more.
  
  Data Sharing
  
  Based on recommendations from the International Committee of Medical Journal Editors (ICMJE) published in the New England Journal of Medicine (NEJM) on June 8, 2017, the CVC recognizes the value and importance of making data …
Conferences and Events
B2K
- 2020 Symposium
  
  The 2020 B2K New Concepts Symposia took place Friday October 23rd as part of the 2020 virtual Canadian Cardiovascular Congress. Program details for B2K20 can be found below:
  
  Webinars
  
  Below you will find full recordings of a selection of webinars that have been held in conjunction with the B2K program. If you have any questions about the B2K webinars, please contact beyond2k@ualberta.ca Breaking News from …
  
  Archive
  
  B2K19 Program B2K18 Program
  
  Contact Us
  
  If you have any questions regarding B2K, please contact beyond2k@ualberta.ca
VICTORIA
VITALITY-HFpEF
Resources
- Clinical Practice Guidelines
  
  ACC/AHA Joint Guidelines These guidelines are a listing of the standards and updates related to diagnosis, management, and care of patients with cardiovascular disease from the American College of Cardiology and the American Heart Association. CCS …
  
  Health Canada Regulations
  
  In this section you will find links to important and useful documents produced by Health Canada which relate to the regulatory functions of the Health Products and Food Branch Inspectorate. This group is responsible for the inspections …
  
  ICH-GCP E6 (R2)
  
  Good Clinical Practice (GCP) is an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. The ICH GCP Guideline was developed with consideration of …
News
About Us
- History
  
  The Canadian VIGOUR Centre (CVC) was established in 1997 as the Canadian arm of the international VIGOUR (Virtual Coordinating Centre for Global Collaborative Cardiovascular Research) Group. Since its inception, our centre has undertaken over 60 …
  
  Vision, Mission, and Core Values
  
  Vision Generate, translate and disseminate knowledge on novel diagnostic and therapeutic strategies in cardiovascular medicine acquired through collaborative research to enhance the health of the citizens of Alberta, Canada, and the world. Mission Aligned with the University of …
  
  CVC Facts and Figures
  
  The following facts and figures highlight some of the CVC’s key accomplishments to date.
  
  Bios
  
  The CVC Faculty are internationally recognized as Thought Leaders in their respective areas of interest, and they collectively represent a diverse field of clinical research. Our faculty are passionately dedicated to advancing the frontiers of …
  
  Relationships with Industry
  
  Relationships with industry disclosure statements for the Canadian VIGOUR Centre’s faculty members are provided below. These statements are considered proprietary and are not to be distributed, downloaded for repeat use, or reproduced in any way …
  
  Collaborators
  
  The CVC has forged strong partnerships with a number of institutions and centres around the world in the pursuit of novel research directions and the advancement of cardiovascular research. The CVC takes great pride in …
  
  Training the Next Generation
  
  The CVC embraces an enthusiastic commitment to fostering a research environment conducive to disciplined academic inquiry, novel approaches to clinically relevant questions, and robust methodologies. We are pleased to offer research opportunities to undergraduates, medical …
  
  Annual Report
  
  We are pleased to share the 2019 CVC annual report. This year's theme, A Decade of Discovery, celebrates the pathway forged by the CVC over the past ten years. Our staff and faculty have all …
Contact

Home > VITALITY-HFpEF

VITALITY-HFpEF

The VITALITY-HFpEF trial (Evaluate the Efficacy and Safety of the Oral sGC Stimulator Vericiguat to Improve Physical Functioning in Daily Living Activities of Patients With Heart Failure and Preserved Ejection Fraction) is designed to determine the efficacy and safety of a novel oral soluble guanylate cyclase stimulator, vericiguat, on quality of life and exercise tolerance in heart failure patients with preserved ejection fraction (HFpEF)

Presentations

The VITALITY-HFpEF study was presented on June 12, 2020 during HFA Discoveries, an online initiative from the European Society of Cardiology Heart Failure Association.

Please note a My ESC account is required to view the on-demand webinar presentation for VITALITY-HFpEF

Publications

Paul W. Armstrong; Carolyn S. P. Lam, Kevin J. Anstrom, Justin Ezekowitz, Adrian F. Hernandez, Christopher M. O’Connor, Burkert Pieske, Piotr Ponikowski, Sanjiv J. Shah, Scott D. Solomon, Adriaan A. Voors, Lilin She, Vanja Vlajnic, Francine Carvalho, Luke Bamber, Robert O. Blaustein, Lothar Roessig, Javed Butler; for the VITALITY-HFpEF Study Group. Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial. JAMA. 2020;324:1512-1521. doi:10.1001/jama.2020.15922.

Javed Butler, Carolyn S P Lam, Kevin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Christopher M O’Connor, Burkert Pieske, Piotr Ponikowski, Sanjiv J Shah, Scott D Solomon, Adriaan A Voors, Yi Wu, Francine Carvalho, Luke Bamber, Robert O Blaustein, Lothar Roessig, Paul W Armstrong. Rationale and Design of the VITALITY-HFpEF Trial. Circ Heart Fail. 2019 May;12:e005998. doi: 10.1161/CIRCHEARTFAILRE.119.005998.

Media Coverage

New Vericiguat Shine May Not Brighten Heart Failure With Preserved LVEF (Medscape)
Audio Editor’s Summary of Vericiguat for HFpEF (JAMA)

Data Sharing

View the VITALITY-HFpEF Data Sharing Appendix here.