Women With Elevated Fasting Glucose Levels may be at Higher Risk of Adverse Pregnancy Outcomes

Congratulations to Drs. Ana Savu, Linn Moore and Padma Kaul, along with their fellow coauthors, on the publication of their article Elevated fasting vs post-load glucose levels and pregnancy outcomes in gestational diabetes: a population-based study in Diabetic Medicine.

It is known that women with gestational diabetes mellitus (GDM) are at an increased risk of developing hypertensive disorders of pregnancy (HDP) and having large for gestational age (LGA) babies. However, there are currently limited data on the relative association between fasting plasma glucose (FPG) vs post‐load (1‐ and/or 2‐h) glucose values on the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes.

Using a large population‐based cohort, the authors found that LGA and HDP rates were significantly higher in pregnancies with elevated FPG than in those with elevated post‐load glucose levels.

Their research concludes that elevated fasting hyperglycaemia in GDM is associated with a higher risk of LGA and HDP than post‐load glucose elevation. The persistence of adverse outcomes despite treatment highlights the need for future research to examine whether fasting hyperglycaemia is a marker of some metabolic derangement that results in adverse outcomes in pregnancy.

Dr. Kaul also spoke about their research findings in Folio here: