Services
- Thought Leadership
  
  With their depth of knowledge and experience, CVC thought leaders are able to both understand and address the multiple challenges associated with the regulatory, financial and operational aspects of clinical research. Some key elements of their research-related …
  
  Clinical Trials Management
  
  With over 20 years of experience in Clinical Trial Operations for Phase II/III/IV and investigator initiated studies, our team brings the expertise and knowledge to deliver a high quality and well executed trial from study …
  
  Biostatistics
  
  The biostatisticians at the CVC provide statistical expertise to study design and analysis, and have experience with a wide variety of data sources. They participate in innovative primary and secondary research in cardiovascular medicine in …
  
  Health Economics and Quality of Life
  
  The CVC has a long history using natural “experiments” in the form of inter-country comparisons to draw inferences about the return on investment in medical care. In the modern era of cost conscious medicine, clinical …
  
  Population Health Surveillance
  
  The CVC is actively involved in examining population-level issues related to access, delivery, treatment, and outcomes of heart disease in Alberta and Canada. Healthcare administrative databases have become a cornerstone in the process of assessing …
  
  Core Labs
  
  ECG Core Lab The ECG Core Laboratory specializes in the processing and analysis of electrocardiographic data from large-scale clinical trials and investigator-initiated research projects. This laboratory has had a major role as the primary coordinating laboratory …
  
  Business Operations
  
  The business office is fundamental to the organizational and financial underpinnings of the CVC. This group is responsible for overseeing all aspects of finance, human resources, IT infrastructure, marketing, and legal matters involving the CVC’s …
Clinical Research
- - Clinical Trials
  - Population Based Research
  Clinical Trials
  
  The section has information on the trials that the CVC is currently working on, some of which are recruiting and others that are in the follow-up or closeout phase. If you are interested in learning …
  
  Population Based Research
  
  Below you will find information about the population based research projects that are currently underway at the CVC. Through the interrogation of registries and population health data, the CVC is steadfastly dedicated to our organization’s …
Publications
- Featured Publications
  
  As a learning organization committed to enhancing the health of current and future generations through research, the CVC relentlessly pursues the generation, translation, and dissemination of new knowledge addressing unmet clinical needs. This section highlights …
  
  Publications Archive
  
  Canadian Cardiac Chronicle
  
  The Canadian Cardiac Chronicle is a quarterly newsletter that includes information about the CVC's current trials and upcoming projects, as well as a list of recent publications from our faculty. The Chronicle is distributed to …
  
  Annual Reports
  
  As an Academic Research Organization, the Canadian VIGOUR Centre is held to a high standard of both fiscal and academic responsibility. Browse through our current and past annual reports below to find out more. The digital …
  
  Data Sharing
  
  Based on recommendations from the International Committee of Medical Journal Editors (ICMJE) published in the New England Journal of Medicine (NEJM) on June 8, 2017, the CVC recognizes the value and importance of making data …
Programs and Events
- - B2K
  - CVC Clinical Trials Colloquium
  B2K
  
  Beyond 2000 (B2K) is a symposium held each year in conjunction with the Canadian Cardiovascular Congress. The symposium is comprised of two sequential sessions – the first on acute coronary syndromes (ACS), and the second …
  
  CVC Clinical Trials Colloquium
  
  The CVC Clinical Trials Colloquium first began in 2014 when Dr. Paul Armstrong (CVC Founding Director) and Tracy Temple (Associate Director, Clinical Trials), brought together 13 Canadian investigative sites to help: Identify major impediments to timely …
Resources
- Clinical Practice Guidelines
  
  ACC/AHA Joint Guidelines These guidelines are a listing of the standards and updates related to diagnosis, management, and care of patients with cardiovascular disease from the American College of Cardiology and the American Heart Association. CCS …
  
  Health Canada Regulations
  
  In this section you will find links to important and useful documents produced by Health Canada which relate to the regulatory functions of the Health Products and Food Branch Inspectorate. This group is responsible for the inspections …
  
  ICH-GCP E6 (R2)
  
  Good Clinical Practice (GCP) is an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. The ICH GCP Guideline was developed with consideration of …
VICTORIA
- Publications
  
  A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator: The VICTORIA Trial.Armstrong PW, Roessig L, Patel MJ, Anstrom KJ, Butler J, Voors AA, Lam CSP, Ponikowski …
  
  Presentations
  
  Late-Breaking Clinical Trial Presentation The VICTORIA trial was presented as a Late-Breaking Clinical Trial on March 28, 2020 at the virtual American College of Cardiology’s 69th Annual Scientific Session Together With World Congress of Cardiology (ACC.20/WCC). Other …
  
  Secondary Analyses
  
  Below is a summary of completed, in progress, and planned secondary analyses for the VICTORIA study. AnalysesStatus (Completed, In Progress, Planned)Related LinksContextual with other trialsCompletedCirculation publicationImpact of natriuretic peptides on result and their evolutionCompletedJACC FF publicationHFA …
  
  Press Releases & Media
  
  Press Releases Patient Enrollment (2016) University of Alberta Press Release Study Results (March 2020) University of Alberta Press ReleaseAmerican College of Cardiology Press ReleaseBayer Press ReleaseMerck Press Release U.S. FDA Approval (January 2021) Merck Press ReleaseBayer Press ReleaseUniversity of Alberta Press …
  
  Data Sharing
  
  VICTORIA Data Sharing Charter (PDF) VICTORIA Research Proposal Form Per the VICTORIA Data Sharing Charter, this form is provided for qualified researchers to submit a data request for patient-level data to the VICTORIA Publications Committee for review. Data …
  
  Lay Summary
  
  VICTORIA Clinical Study Results Lay Summary (PDF)
  
  FAQs
  
  Download the VICTORIA FAQs Document (PDF)
VITALITY-HFpEF
About Us
- History
  
  The Canadian VIGOUR Centre (CVC) was established in 1997 as the Canadian arm of the international VIGOUR (Virtual Coordinating Centre for Global Collaborative Cardiovascular Research) Group. Since its inception, our centre has undertaken over 60 …
  
  Vision, Mission, and Core Values
  
  Vision Generate, translate and disseminate knowledge on novel diagnostic and therapeutic strategies in cardiovascular medicine acquired through collaborative research to enhance the health of the citizens of Alberta, Canada, and the world. Mission Aligned with the University of …
  
  Facts and Figures
  
  The following facts and figures highlight some of the CVC’s key accomplishments to date.
  
  Bios
  
  The CVC Faculty are internationally recognized as Thought Leaders in their respective areas of interest, and they collectively represent a diverse field of clinical research. Our faculty are passionately dedicated to advancing the frontiers of …
  
  Relationships with Industry
  
  Relationships with industry disclosure statements for the Canadian VIGOUR Centre’s faculty members are provided below. These statements are considered proprietary and are not to be distributed, downloaded for repeat use, or reproduced in any way …
  
  Collaborators
  
  The CVC has forged strong partnerships with a number of institutions and centres around the world in the pursuit of novel research directions and the advancement of cardiovascular research. The CVC takes great pride in …
  
  Training the Next Generation
  
  The CVC embraces an enthusiastic commitment to fostering a research environment conducive to disciplined academic inquiry, novel approaches to clinically relevant questions, and robust methodologies. We are pleased to offer research opportunities to undergraduates, medical …
  
  Annual Report
  
  We are pleased to share the 2021 CVC annual report. This year’s theme, Global Vision ⟷ Local Action, highlights a variety of the CVC’s activities that have started at a global or national scale and have …
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